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SHMT1-mediated metabolism also influences the ability of tumor cells to synthesize crucial lipids, like sialic acid N-acetylneuraminic acid, which supports the release of cytokines (IL-6 and IL-8) involved in ovarian cancer cells proliferation and migration in mouse models [119]

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Similarly, in response to regenerative signals in WT mice (e.g., after partial hepatectomy or growth factor stimulation in vitro), diploid hepatocytes entered and progressed through the cell cycle more rapidly than polyploids